Amyloidosis happens when abnormal protein material called amyloid builds up in organs. Some forms of this disease are genetic and are inherited (for example, Chinese Shar-Pei have increased risk). Other cases happen after serious long-term inflammation, immune system disorders, some cancers, or heartworm disease—though often the cause is unknown.
Amyloid can build up in one place or throughout the body. It causes damage by crowding out normal cells. It can be fatal if it heavily affects major organs like the kidneys, liver, or heart. Small deposits of amyloid are common in older animals and might not cause any signs.
Amyloidosis is hard to diagnose because it can develop quietly. A veterinarian might suspect it when a dog with long-term inflammation later develops kidney or liver failure.
There is no treatment that reliably removes amyloid deposits or prevents them once the process begins.
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Also see professional content regarding amyloidosis.
