Merck Manual

Please confirm that you are a health care professional

Loading

Clinical Pathology in Neurologic Disease

By

Thomas Schubert

, DVM, DACVIM, DABVP, Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

Last full review/revision Jul 2013 | Content last modified Jul 2013

Abnormalities of serum glucose, liver enzymes, BUN, bile acids, ammonia, electrolytes, or blood gases can occur with metabolic dysfunctions. Serum cholinesterase is decreased in acute organophosphate toxicity, and serum lead determinations are increased in lead toxicity. Serum thyroid and cortisol determinations and stimulation tests are useful to detect endocrinopathies. Serum titers or PCRs for viral, fungal, protozoal, and rickettsial organisms can be evaluated. Serum muscle enzymes, especially CK, may be increased in myopathies. Serum acetylcholine receptor antibodies can be detected in dogs and cats with myasthenia gravis, and type II M muscle antibody titers are used to confirm masticatory muscle myositis. Muscle and nerve biopsies are essential for diagnosis and characterization of many neuromuscular disorders. In some cases, brain biopsy is necessary to confirm and characterize an inflammatory or neoplastic process so that proper antimicrobial therapy, chemotherapy, or radiation therapy can be administered.

Others also read

Also of Interest

Videos

View All
Paroxysmal dyskinesia, dog
Video
Paroxysmal dyskinesia, dog
One form of paroxysmal dyskinesia. Note the lack of autonomic signs (lack of hypersalivation)...
Sulfur-induced polioencephalomalacia, steer
Video
Sulfur-induced polioencephalomalacia, steer
Steer with sulfur-induced polioencephalomalacia. The steer is depressed, blind, does not have...

SOCIAL MEDIA

TOP