Merck Manual

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Negative feedback, pituitary-adrenal axis in dogs
neg-feedback-pituitary-adrenal-axis-dogs-kemppainen-sized
Negative feedback, pituitary-adrenal axis in dogs

    Negative feedback is critical to the control of hormones in the pituitary-adrenal axis of dogs. A. Normal negative feedback optimizes pituitary and adrenal functions. B. Resistance to negative feedback is characteristic of pituitary-dependent hyperadrenocorticism. C. A high amount of negative feedback is present with functional adrenocortical tumors (adrenal-dependent hyperadrenocorticism).

Courtesy of Dr. Robert Kemppainen.