Negative feedback is critical to the control of hormones in the pituitary-adrenal axis of dogs. A. Normal negative feedback optimizes pituitary and adrenal functions. B. Resistance to negative feedback is characteristic of pituitary-dependent hyperadrenocorticism. C. A high amount of negative feedback is present with functional adrenocortical tumors (adrenal-dependent hyperadrenocorticism).
Courtesy of Dr. Robert Kemppainen.