Adrenal

Adrenal

(primary)

Primary hypoadrenocorticism

Addison disease, loss of cortisol and aldosterone

Occasional in dogs and cats

Functional adrenal tumor (hyperadrenocorticism [Cushing syndrome])

Occasional in dogs; common in ferrets but involves secretion of excess sex steroids

Pituitary

(secondary)

Secondary hypoadrenocorticism

Low cortisol only

Very occasional in dogs and cats

Pituitary-dependent hyperadrenocorticism(Cushing disease)

Common in dogs

Thyroid

Thyroid

(primary)

Primary hypothyroidism

Common in dogs

Hyperthyroidism

Very common in cats

Pituitary

(secondary)

Secondary hypothyroidism

Low TSH

Rare in dogs or cats

Secondary hyperthyroidism

High TSH

Very rare in dogs and cats

Parathyroid

Parathyroid

(primary)

Primary hypoparathyroidism

Low PTH

Rare in dogs or cats

Primary hyperparathyroidism

High PTH

Occasional in dogs and cats

Kidney or diet

(secondary)

Not reported

Secondary hyperparathyroidism

Sometimes associated with kidney disease in dogs and cats

Pancreas

Pancreas

(primary)

Diabetes mellitus type I

Low insulin

Common in dogs

Insulinoma

High insulin

Occasional in dogs; common in ferrets

Multiple sites, including pancreas

Diabetes mellitus type II

Normal or high insulin

Common in cats

Not reported