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Dosage Modifications of Aminoglycosides in Renal Failure

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Fold Increase Above Normal Serum or Plasma Creatinine Concentration	Dose and Dosage Interval
2-fold increase	Full dose at usual dosage interval or increase interval to 50% plus usual dosing interval (eg, 36 h)
3- to 4-fold increase	Full dose at double usual dosage interval
>4-fold increase	Aminoglycosides contraindicated