Merck Manual

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Dosage Modifications of Aminoglycosides in Renal Failure

Dosage Modifications of Aminoglycosides in Renal Failure

Fold Increase Above Normal Serum or Plasma Creatinine Concentration

Dose and Dosage Interval

2-fold increase

Full dose at usual dosage interval or increase interval to 50% plus usual dosing interval (eg, 36 h)

3- to 4-fold increase

Full dose at double usual dosage interval

>4-fold increase

Aminoglycosides contraindicated