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Merck Manual
Veterinary Manual
The trusted provider of veterinary information since 1955

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VETERINARY PET
Dosage Modifications of Aminoglycosides in Renal Failure

Dosage Modifications of Aminoglycosides in Renal Failure

Fold Increase Above Normal Serum or Plasma Creatinine Concentration

Dose and Dosage Interval

2-fold increase

Full dose at usual dosage interval or increase interval to 50% plus usual dosing interval (eg, 36 h)

3- to 4-fold increase

Full dose at double usual dosage interval

>4-fold increase

Aminoglycosides contraindicated

Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world.  The Merck Veterinary Manual was first published in 1955 as a service to the community.  The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Vet Manual outside of North America.

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