Dosages of Antifungals for Respiratory Therapy

Drug

Dose, Route, Frequency, Species

Amphotericin B

Nebulization: 1 mg/mL solution in sterile water or saline for 15 minutes, q 6–12 h (avian)

Intratracheal: 1 mg/kg, q 8–12 h (avian)

Clotrimazole

Nebulization: 1% aqueous solution for 30 minutes, q 24 h (avian)

Intratracheal or direct air sac administration: 10 mg/kg (avian)

Intranasal: Instill into nasal cavity under general anesthesia for 1 hour, rotating head q 15 min (dogs)

Miconazole

45 minutes/day (avian)

Intranasal: 2% miconazole (horses)

Enilconazole

Intranasal: 5% solution, instillation under general anesthesia for 1 hour, rotating head q 15 min (dogs)

Topical: Instill twice daily via nasal or guttural pouch catheter, q 12 h (horses)

Terbinafine

Nebulization: 1 mg/mL in aqueous solution for 20 minutes, q 8 h (avian)