Dosages of Cephalosporins
Dosages of Cephalosporins
Cephalosporin | Species | Dosage | Notes |
|---|---|---|---|
Cephalexin | Cats | 15–35 mg/kg, PO, q 6–12 h | |
Dogs | 15–45 mg/kg, PO, q 6–12 h | ||
Cefazolin | Dogs, cats | 15–35 mg/kg, IM, SC, or IV, q 6–8 h | |
Horses | 10–20 mg/kg, IV, q 6–8 h; 15–20 mg/kg, IV, q 8–12 h (foals) | ||
Cefpodoxime | Dogs, cats | 5–10 mg/kg, PO, q 12–24 h | |
Foals | 10 mg/kg, PO, q 6–12 h | Not absorbed in adult horses | |
Cefovecin | Dogs, cats | 8 mg/kg, SC, q 14 d | |
Cefoxitin | Dogs, cats | 20–30 mg/kg, IV, q 6–8 h | |
Cefotaxime | Dogs, cats | 50 mg/kg, IV, q 12 h | |
Foals | 20–40 mg/kg, IV, q 6–12 h | ||
Cefadroxil | Dogs, cats | 22 mg/kg, PO, q 12 h | |
Ceftiofur sodium | Horses | 2.2–4.4 mg/kg, IV or IM, q 12–24 h; 10 mg/kg, IM or IV, q 6–12 h (foals) | |
Cattle | 1.1–-2.2 mg/kg, IM or SC, q 24 h for 3–5 days Acute postpartum metritis: 2.2 mg/kg, IM or SC (2 mL sterile suspension per 45 kg [100 lb]), daily q 24 h for 5 consecutive days. Do not inject more than >15 mL per injection site). Bovine respiratory disease (BRD) and acute bovine interdigital necrobacillosis: 1.1 – 2.2 mg/kg, IM or SC (1– 2 mL sterile suspension per 45kg [100 lb]), q 24 h for a total of 3 consecutive days. | ELDU prohibited | |
Swine | For swine bacterial respiratory infections (label dosage; FDA-approved): 3 –5 mg/kg, IM, q 24 h for a total of 3 consecutive days | ELDU prohibited | |
Ceftiofur crystalline-free acid | Horses | 6.6 mg/kg, IM, at 0 and 96 h; 6.6 mg/kg, SC, q 72 h (foals) | |
Cattle | Bovine respiratory disease (BRD) and bovine interdigital necrobacillosis in beef, non-lactating dairy, and lactating dairy cattle: 6.6 mg/kg, SC, once in the base of the ear Acute metritis in lactating dairy cattle: 6.6 mg/kg, SC, in the base of the ear, repeat dose (in opposite ear) in 72 h. | ELDU prohibited | |
Swine | Swine respiratory disease (SRD): 5.0 mg/kg, IM, once in the post-auricular region; do not give more than >2 mL per injection site | ELDU prohibited | |
Cephalosporins are prohibited from extralabel drug use (ELDU) in major food-producing animal species (cattle, swine, chickens, and turkeys) in the US. Dosages for any labeled food producing species should reflect the approved product name, approved species, approved indication, approved dosage, approved route of administration, and approved frequency and duration only. | |||