Dosages of Potentiated Sulfonamides

Combination Sulfonamide

Species

Dosage, Route, and Frequency

Notes

Trimethoprim-sulfadiazine

Dogs

30 mg/kg, PO, q 24 h

Approved veterinary products are available with a trimethoprim-to-sulfadiazine ratio of 1:4; dosages are based on the total mg of the combination.

Cats

15 mg/kg, PO, q 12 h

ELDU

Horses

24 mg/kg, PO, q 12 h; 30 mg/kg, PO, q 12–24 h

Trimethoprim-sulfamethoxazole

Cats

15 mg/kg, PO, q 12 h

ELDU

Dogs

30–45 mg/kg, PO, q 12 h

ELDU

Horses

30 mg/kg, PO, q 12–24 h

ELDU

Ormetoprim-sulfadimethoxine

Dogs

55 mg/kg, PO, once, followed by 27.5 mg/kg, PO, q 24 h

ELDU, extralabel drug use