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Elimination, Distribution, and Clearance of Cephalosporins

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Cephalosporin	Species	Route	Elimination Half-life (min)	Volume of Distribution (L/kg)	Clearance (mL/kg/min)
Cefazolin	Horses	IV	45	0.19	5.5
	Dogs	IV	180	0.383	2.5
	Cats	IV	71	0.29	3.3
Cefotaxime	Sheep	IV	23	0.19	8.7
	Cats	IV	58	0.182	2.8
	Horses	IV	36	0.29	5.2
Cefpodoxime	Dog	IV	280	0.150	0.38
Cefovecin	Dog	IV	5.5 days	0.09
	Cats	IV	7.6 days	0.09	0.006
Cephalexin	Dogs	IV	117	0.37	2.83
	Sheep	IV	90	0.175	2
Cefadroxil	Dogs		120	—	—
	Cats		150–180	—	—
	Horses	IV	48	0.46	7
Ceftiofur sodium	Cattle	IV	216	0.393	1.3
	Horses	IV	6.7	—	—