Elimination, Distribution, and Clearance of Cephalosporins
Elimination, Distribution, and Clearance of Cephalosporins
Cephalosporin | Species | Elimination Half-life (min) | Volume of Distribution (mL/kg) | Clearance (mL/kg/min) |
|---|---|---|---|---|
Cefazolin | Horses | 45 | 188 | 5.5 |
Cefotaxime | Sheep | 25 | 134 | 9.0 |
Cefpodoxime | Dog | 300 | 150 | |
Cefovecin | Dog | 5.5 days | 90 | |
Cephalexin | Dogs | 7.3–9 hr | — | — |
Cefadroxil | Dogs | 120 | — | — |
Cats | 150–180 | — | — | |
Ceftiofur | Cattle | ~360 | — | — |