Merck Manual

Please confirm that you are a health care professional

honeypot link

Centronuclear Myopathy

(Labrador Retriever Myopathy)

By

Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Nov 2020

This inherited (autosomal recessive) condition is characterized by a type 2 muscle fiber deficiency and is now called centronuclear myopathy. Clinical signs are seen at <5 months of age and include skeletal muscle atrophy, stunted growth, ataxia, and weakness. Signs are progressive until the animal reaches maturity, when they stabilize. Animals may have a normal life span. Diagnosis is by creatinuria, muscle biopsy, and electromyography. Histology reveals increased connective tissue around muscle fibers and staining deficiency of type II fibers. Myotonic discharges are seen with electromyography. There is no effective treatment, although warm housing and L-carnitine supplementation may make affected dogs more comfortable. This condition has different clinical features than exercised-induced collapse in Labrador Retrievers.

For More Information

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Test your knowledge

Musculoskeletal Disorders in Large Animals
A seven-year-old Quarter horse gelding presents with a 1-week history of mild lameness. During the examination, the horse raises his head as he places weight on his left forelimb and drops it when placing weight on the right forelimb. Which limb is most likely affected in this horse?
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website 
TOP