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Exertional Myopathy in Dogs

(Rhabdomyolysis, Tying-up, Monday Morning Disease)

By

Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Nov 2020

This acute exertional myopathy of racing Greyhounds and working dogs is characterized by muscle ischemia secondary to exercise or excitement. Avascularity and lactic acidosis cause muscular lysis, myoglobin release, and a nephropathy.

Clinical signs include muscle pain and swelling 24–72 hours after racing. Severe cases are characterized by stiffness, hyperpnea, collapse, myoglobinemia, and acute renal failure. Urinalysis reveals myoglobinuria; serum potassium, phosphorus, and muscle enzymes are increased. Treatment includes supportive care such as IV fluids, bicarbonate, body cooling, rest, and muscle relaxants (eg, diazepam). Prognosis depends on severity. (Also see Exertional Myopathies in Horses Exertional Myopathies in Horses Exertional myopathy in horses is a syndrome of muscle fatigue, pain, or cramping associated with exercise. Less common exertional myopathies that cause exercise intolerance without muscle necrosis... read more .)

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In all animals, the motor unit of skeletal muscle consists of the motor neuron, the neuromuscular junction, and muscle fibers. Muscle dysfunction—such as ataxia, paresis, or paralysis—most commonly originates in which of the following locations?
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