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Exertional Myopathy in Dogs

(Rhabdomyolysis, Tying-up, Monday Morning Disease)

By

Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Nov 2020

This acute exertional myopathy of racing Greyhounds and working dogs is characterized by muscle ischemia secondary to exercise or excitement. Avascularity and lactic acidosis cause muscular lysis, myoglobin release, and a nephropathy.

Clinical signs include muscle pain and swelling 24–72 hours after racing. Severe cases are characterized by stiffness, hyperpnea, collapse, myoglobinemia, and acute renal failure. Urinalysis reveals myoglobinuria; serum potassium, phosphorus, and muscle enzymes are increased. Treatment includes supportive care such as IV fluids, bicarbonate, body cooling, rest, and muscle relaxants (eg, diazepam). Prognosis depends on severity. (Also see Exertional Myopathies in Horses.)

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Musculoskeletal Disorders in Large Animals
A seven-year-old Quarter horse gelding presents with a 1-week history of mild lameness. During the examination, the horse raises his head as he places weight on his left forelimb and drops it when placing weight on the right forelimb. Which limb is most likely affected in this horse?
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