Merck Manual

Please confirm that you are a health care professional

honeypot link

Iodides

By

Dawn Merton Boothe

, DVM, PhD, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

Last full review/revision Nov 2015 | Content last modified Nov 2015

Sodium and potassium iodide have both been used to treat selected bacterial, actinomycete, and fungal infections, although sodium iodide is preferred. The in vivo effects of iodides against fungal cells are not well understood. Iodide is readily absorbed from the GI tract and distributes freely into the extracellular fluid and glandular secretions. Iodide concentrates in the thyroid gland (50 times corresponding plasma level) and to a much lesser degree in salivary, lacrimal, and tracheobronchial glands. Longterm use at high levels leads to accumulation in the body and to iodinism.

Clinical signs of iodinism include lacrimation, salivation, increased respiratory secretions, coughing, inappetence, dry scaly skin, and tachycardia. Cardiomyopathy has been reported in cats. Host defense systems, such as decreased immunoglobulin production and reduced phagocytic ability of leukocytes, are also impaired. Iodinism may also lead to abortion and infertility.

Sodium iodide has been used successfully to treat cutaneous and cutaneous/lymphadenitis forms of sporotrichosis; attempts to control various other mycotic infections with iodides yield equivocal results.

The dosage for sodium iodide (20% solution) is 44 mg/kg/day, PO, for dogs, and 22 mg/kg/day, PO, for cats. The dosage for horses is 125 mL of 20% sodium iodide solution, IV, daily for 3 days, then 30 g, PO, daily for 30 days after clinical remission. The dosage rate for treating actinomycosis and actinobacillosis in cattle is 66 mg/kg, by slow IV, repeated weekly. Potassium iodide should never be injected IV.

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Test your knowledge
Systemic Pharmacotherapeutics of the Cardiovascular System
Dogs and cats with left-side congestive heart failure (CHF) can develop respiratory distress due to pulmonary edema. Which of the following intravenous diuretics is the most appropriate treatment for life-threatening pulmonary edema caused by CHF?
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website 
TOP