Merck Manual

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Cyclopiazonic Acid in Poultry


Frederic J. Hoerr

, DVM, PhD, Veterinary Diagnostic Pathology, LLC

Last full review/revision Sep 2019 | Content last modified Oct 2019

Cyclopiazonic acid is a metabolite of Aspergillus flavus, which is the predominant producer of aflatoxin in feeds and grains. In chickens, cyclopiazonic acid causes impaired feed conversion, decreased weight gain, and mortality with lesions forming in the proventriculus, gizzard, liver, and spleen. The proventriculus is dilated, and the mucosa is thickened and variably ulcerated.

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