Merck Manual

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Subinvolution of Placental Sites in Small Animals

By

Mushtaq A. Memon

, BVSc, PhD, DACT, Department of Veterinary Clinical Sciences, Washington State University

Medically Reviewed Nov 2013 | Modified Oct 2022

Subinvolution of placental sites (SIPS) is abnormal repair of the endometrial placental sites. This disorder is most common in young bitches (< 3 yr old) after whelping a first litter. Bitches with SIPS are normal except for hemorrhagic uterine discharge passing from the vulva for several weeks postpartum. Diagnosis is by exclusion; differentials include metritis, vaginitis, and cystitis. Treatment is supportive. Ovariohysterectomy is recommended for bitches that become anemic enough to require transfusion and for bitches not intended for future breeding.

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