Merck Manual

Please confirm that you are a health care professional

honeypot link

Necrotic Laryngitis in Cattle

(Calf diphtheria, Laryngeal necrobacillosis)


John Campbell

, DVM, DVSc, Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan

Last full review/revision Mar 2015 | Content last modified Mar 2015

Fusobacterium necrophorum, a gram-negative, nonsporeforming anaerobe, is a normal inhabitant of the alimentary, respiratory, and genital tract of animals. The organism is an opportunistic pathogen that causes several necrotic conditions in animals (ie, necrobacillosis), including necrotic laryngitis.

Necrotic laryngitis is an acute or chronic F necrophorum infection of the laryngeal mucosa and cartilage of young cattle, characterized by fever, cough, inspiratory dyspnea, and stridor. It occurs primarily in feedlot cattle 3–18 mo of age; however, cases have been documented in calves as young as 5 wk and in cattle as old as 24 mo. Cases are seen worldwide and year round but appear to be more prevalent in fall and winter.


Predisposing factors are not fully understood. F necrophorum, commonly isolated from laryngeal lesions of affected cattle, is unable to penetrate intact mucous membranes. Laryngeal contact ulcers, a common finding in slaughtered cattle, are thought to provide a portal of entry for F necrophorum.

Transmission, Epidemiology, and Pathogenesis:

Necrotic laryngitis is most common where cattle are closely confined under unsanitary conditions or in feedlots. The prevalence in feedlot calves is estimated to be 1%–2%. Most cases are sporadic and occur year round, but disease peaks in fall and winter. Mixed upper respiratory tract infections (caused by infectious bovine rhinotracheitis virus and parainfluenza-3 virus; Mycoplasma spp; and bacteria, including Pasteurella and Haemophilus), and the coughing and swallowing associated with these infections, may predispose feedlot cattle to develop laryngeal contact ulcers. These ulcers on the vocal processes and medial angles of arytenoid cartilages are thought to provide a portal of entry for F necrophorum.

F necrophorum causes inflammation, necrosis, and edema in the laryngeal mucosa, resulting in variable narrowing of the rima glottidis and inspiratory dyspnea and stridor. If infection extends into the laryngeal cartilage, laryngeal chondritis develops, which may lead to a chronically deformed larynx. Pharyngeal invasion by the organism causes discomfort characterized by painful swallowing motions. Systemic signs of illness have been attributed to the exotoxin produced by F necrophorum.

Clinical Findings:

Initially, a moist, painful cough is noticed. Severe inspiratory dyspnea, characterized by open-mouth breathing with the head and neck extended, and loud inspiratory stridor are common findings. Ptyalism; frequent, painful swallowing motions; bilateral, purulent nasal discharge; and a fetid odor to the breath may also be present. Systemic signs may include fever (106°F [41.1°C]), anorexia, depression, and hyperemia of the mucous membranes. Untreated calves die in 2–7 days from toxemia and upper airway obstruction. Longterm sequelae include aspiration pneumonia and permanent distortion of the larynx, resulting in a chronic harsh cough and inspiratory dyspnea.


Lesions are typically located over the vocal processes and medial angles of arytenoid cartilages. Acute lesions are characterized by edema and hyperemia surrounding a necrotic ulcer in the laryngeal mucosa; lesions may spread along the vocal folds and processes to involve the cricoarytenoideus dorsalis muscle. In chronic cases, lesions consist of necrotic cartilage associated with a draining tract surrounded by granulation tissue.


Clinical signs are usually sufficient to establish a diagnosis. However, because numerous other conditions can cause signs of upper airway obstruction, the larynx should be visually inspected to confirm a diagnosis. This can be accomplished by means of an orally inserted speculum, laryngoscopy, endoscopy, or radiography, but care must be exercised to avoid further respiratory embarrassment. A tracheostomy should be performed before laryngoscopic or endoscopic examination in cattle with severe inspiratory dyspnea. Differential diagnoses include pharyngeal trauma; severe viral laryngitis (eg, infectious bovine rhinotracheitis); actinobacillosis; and laryngeal edema, abscesses, trauma, paralysis, or tumors.

Treatment and Control:

Oxytetracycline (11 mg/kg, IV or SC, bid, or 20 mg/kg of long-acting tetracycline, SC, every 72 hr) or procaine penicillin (22,000 U/kg, IM, bid) are the antimicrobials of choice. NSAIDs (aspirin, 100 mg/kg, PO, bid; flunixin, 1.1–2.2 mg/kg, IV, once daily or divided bid; or ketoprofen, 3 mg/kg/day, IM or IV, for up to 3 days) are used to decrease the fever and laryngeal inflammation and edema. A single dose of dexamethasone (0.2–0.5 mg/kg, IV or IM) may be used to decrease laryngeal edema in animals with severe respiratory distress. A tracheostomy is indicated in cattle with severe inspiratory dyspnea. Good nursing care should be provided. Intravenous fluids may be required in dehydrated animals. The prognosis is good for early cases treated aggressively; chronic cases require surgery under general anesthesia to remove necrotic or granulation tissue and to drain laryngeal abscesses. A 60% success rate has been reported for surgical intervention in advanced cases.

There are no specific control measures for necrotic laryngitis; however, the proposed pathogenesis suggests that control measures for common respiratory pathogens may be beneficial.

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Test your knowledge
Respiratory Diseases of Small Animals
An obese, 13-year-old, neutered male Pomeranian is brought to the veterinarian because of a cough that has worsened over the last 3 to 4 months. His owner reports that the cough sounds like a “goose honk,” occurs when the dog is excited (e.g., when the doorbell rings), and is unproductive of sputum. The dog then appears to have trouble breathing after coughing. On physical examination, auscultation of the heart and lungs is normal, and the veterinarian is unable to stimulate the cough. The owner declines thoracic x-rays due to financial concerns. Which of the following is the most likely diagnosis?
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website