Merck Manual

Please confirm that you are a health care professional


Interstitial Nephritis, Glomerulonephritis, and Vasculitis in Small Animals


Scott A. Brown

, VMD, PhD, DACVIM, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia

Last full review/revision Sep 2015 | Content last modified Sep 2015

Acute interstitial nephritis in dogs is caused most often by Leptospira interrogans (see Leptospirosis in Dogs). Cats rarely develop leptospirosis, and clinical signs are less severe than in dogs. Other infectious causes of nephritis in dogs include Leishmania donovani and Borrelia burgdorferi. These systemic vectorborne diseases are endemic in specific geographic areas. Glomerulonephritis is the predominant renal pathology, so these are considered immune complex diseases rather than true urinary tract infections. Toxoplasmosis can cause pyogranulomas in the kidneys or elsewhere in the urinary system. Systemic infectious diseases that cause vasculitis in cats or dogs (eg, feline infectious peritonitis, Rocky Mountain spotted fever) may also cause kidney disease.

Others also read

Also of Interest


View All
Overview of Physiologic pH and Buffers
Overview of Physiologic pH and Buffers
Overview of the Role of the Kidneys in Acid-Base Balance
Overview of the Role of the Kidneys in Acid-Base Balance