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Intestinal Salmonellosis in Pigs


Eric R. Burrough

, DVM, PhD, DACVP, Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University

Reviewed/Revised Sep 2021 | Modified Oct 2022
Topic Resources

Enteropathogenic salmonellae cause inflammation and necrosis of the small and large intestines, resulting in diarrhea. Infection with certain serotypes may be accompanied by generalized sepsis. Pigs of all ages are susceptible; however, intestinal salmonellosis is most common in weaned and growing-finishing pigs.

Etiology and Pathogenesis of Intestinal Salmonellosis in Pigs

Salmonella enterica serotype Choleraesuis, variety Kunzendorf (S Choleraesuis), is one of the most common Salmonella species affecting pigs. It sometimes produces necrotizing enterocolitis; more commonly, it is associated with septicemic disease characterized by hepatitis and pneumonia. Intestinal salmonellosis Salmonellosis in Animals Salmonellosis is infection with Salmonella spp bacteria. It affects most animal species as well as humans and is a major public health concern. The clinical presentation can range from... read more Salmonellosis in Animals in pigs has traditionally been associated with either S Choleraesuis or S Typhimurium. Recently, however, S enterica serotype 4,[5],12:i:- has been detected with increasing frequency in pigs with clinical signs of disease, and it has become one of the predominant serotypes isolated from diseased swine. S Typhisuis infection is less common and is associated with chronic ulcerative colitis. Sources of infection with these serotypes are primarily asymptomatic carrier pigs; however, rodents and contaminated feed and premises may also be sources.

Numerous other serotypes of salmonellae are present in pigs, some of which have been associated with human foodborne illness. Common serotypes isolated from swine in addition to those previously noted are S Agona, S Derby, S Heidelberg, and S Infantis. These serotypes may be associated with mild to moderate diarrhea in swine and may be resistant to multiple antimicrobials.

Clinical Findings of Intestinal Salmonellosis in Pigs

Intestinal salmonellosis is most often observed in pigs from weaning up to about 5 months old; however, it can occur at other ages. Affected pigs are commonly febrile, with reduced feed intake, and have liquid yellow feces that may contain shreds of necrotic debris. Diarrhea in individual pigs usually lasts 3–7 days, and it may recur for multiple bouts.


Pigs infected with enteropathogenic salmonellae (S Choleraesuis, S Typhimurium, and S 4,[5],12:i:-) have an inflamed, segmentally thickened distal small intestine and colon, usually with necrotic debris on the mucosal surface. Mesenteric lymph nodes are variably enlarged, edematous, and reddened. Mucosal ulceration may or may not be evident, and a small amount of hemorrhage may be observed in acute cases. Rectal strictures Rectal Strictures in Pigs In growing pigs, rectal strictures are sequelae of severely traumatized rectal prolapses or of infections that interfere with rectal blood supply. The former cause sporadic cases; the latter... read more occasionally occur as a sequela. S Typhisuis infection produces distinctive lesions that include multifocal, chronic, deep mucosal ulcers with central cores of caseonecrotic debris ("button" ulcers).

Diagnosis of Intestinal Salmonellosis in Pigs

  • Confirmation via culture and serotyping

  • Histologic examination

Culture of feces or intestinal mucosa using selective media, with or without enrichment, is useful to isolate salmonellae from clinical samples and can be completed in a few days. Culture of enlarged mesenteric lymph nodes is of higher diagnostic specificity for enteropathogenic strains and should ideally be performed in tandem with mucosal or fecal cultures. Culture is typically followed by serotyping to confirm the serotype involved. PCR assays are increasingly available, often with serotype-level specificity, that can reduce the time to final etiologic diagnosis. Histologic examination of affected intestine and liver tissue to differentiate intestinal salmonellosis from proliferative enteropathy Porcine Proliferative Enteropathy Porcine proliferative enteropathy is a common diarrheal disease of growing-finishing pigs and young breeding pigs, characterized by hyperplasia and inflammation of the jejunum, ileum, cecum... read more Porcine Proliferative Enteropathy and swine dysentery Swine Dysentery Swine dysentery is a mucohemorrhagic diarrheal disease of pigs that is limited to the large intestine. Swine dysentery is most often observed in growing-finishing pigs and is associated with... read more Swine Dysentery is of high diagnostic value.

Treatment and Control of Intestinal Salmonellosis in Pigs

  • Antimicrobial treatment based on results of minimum inhibitory concentration testing

  • Vaccination

Parenteral administration of antimicrobials to acutely ill pigs and medication of the affected group via water or feed may decrease the severity of an outbreak of intestinal salmonellosis. Neomycin and lincomycin-spectinomycin are commonly administered water medications. Susceptibility testing of isolated organisms is useful to select an appropriate antimicrobial. Thorough cleaning and disinfection of contaminated facilities and elimination of the source of the organism decrease the likelihood of repeated epidemics. Most animals recover; however, some are persistently infected and shed the organism intermittently. Subclinically infected animals are a contamination risk around the time of slaughter.

Live avirulent vaccines administered either intranasally or via drinking water are effective for prevention of disease caused by S Choleraesuis and S Typhimurium. Avirulent vaccines may also effectively reduce levels of salmonellae in the tissues of swine at slaughter.

Key Points

  • S Typhimurium, S 4,[5],12:i:-, and S Choleraesuis are common causes of intestinal salmonellosis in pigs.

  • Culture is important for confirmation of diagnosis and serotyping.

  • Vaccination may help prevent disease and reduce shedding.

For More Information

  • Naberhaus SA, et al. Emergence of Salmonella enterica serovar 4,[5],12:i:- as the primary serovar identified from swine clinical samples and development of a multiplex real-time PCR for improved Salmonella serovar-level identification. J Vet Diagn Invest. 2019;31(6):818–827.

  • Griffith RW, et al. Salmonellosis. In: Zimmerman JJ, et al, eds. Diseases of Swine, 11th ed. John Wiley and Sons, Inc;2019: 912–925.

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