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Bacterial Diseases of Pet Birds


Sharman M. Hoppes

, DVM, ABVP (Avian), Texas A and M University

Last full review/revision Oct 2015 | Content last modified Oct 2015
Topic Resources

Bacterial diseases are common in pet birds and should be considered in the differential list of any sick bird. Inappropriate husbandry and nutrition are often contributing factors. Neonates and young birds are especially susceptible. GI and respiratory infections are most common and can lead to systemic disease.

Normal bacterial flora of companion birds include Lactobacillus, Corynebacterium, nonhemolytic Streptococcus, Micrococcus spp, and Staphylococcus epidermidis.

The most commonly reported pathogens are gram-negative bacteria (Klebsiella, Pseudomonas, Aeromonas, Enterobacter, Proteus, and Citrobacter spp, Escherichia coli, and Serratia marcescens). Pasteurella spp have been reported as possible septicemic agents in birds attacked by pet cats or rats. Mycobacterium and Chlamydia are common intracellular bacterial pathogens. Infections with Salmonella spp are occasionally seen.

The most common gram-positive bacterial pathogens are Staphylococcus aureus, S intermedius, Clostridium, Enterococcus, Streptococcus, and other Staphylococcus spp. Methicillin-resistant S aureus (MRSA) is rare but has been documented. Mycoplasma spp have been implicated in chronic sinusitis, often found in cockatiels. This organism is difficult to culture, and the true incidence is unknown. Staphylococci and streptococci (especially hemolytic strains) and Bacillus spp are thought to be responsible for several dermatologic conditions in psittacine birds. Staphylococci are often isolated from lesions of pododermatitis (bumblefoot) in many avian species.

Clostridial organisms are common secondary invaders of damaged cloacal tissue in birds with cloacal prolapse or papillomatosis. Several specific syndromes of birds can arise from various species of clostridia. A Gram stain or anaerobic culture is necessary to identify these organisms.

Diagnosis is based on clinical signs and results of cytologic examination and culture of tissue or swab samples. A Gram stain is used to identify normal flora, yeast, and spore-forming bacteria. Culture is needed to identify specific organisms and their sensitivity to antibiotics. Samples can be obtained from the respiratory, GI, urinary, and reproductive tracts. Sample sites for culture and cytology include the choanal slit, sinus, cloaca, wounds, conjunctiva, internal organs (via ultrasound-guided fine-needle aspirates, endoscopic examination, or surgery), and blood.

Treatment is based on location of infection and results of culture and sensitivity testing. See table: Antimicrobials Used in Pet Birds for a partial list of frequently recommended antimicrobials.


Antimicrobials Used in Pet Birds


Dose, Route, and Frequencyb

Amikacin sulfate

15 mg/kg, IM, bid


125 mg/kg, PO, tid


50 mg/kg/day, PO

Ceftazidime sodium

75 mg/kg, IM, tid


25 mg/kg, PO, bid


100 mg/kg, PO, bid for 5 days to treat Clostridium


25 mg/kg, PO, bid for 45 daysc

Doxycycline injectable, 20 mg/mL

75–100 mg/kg, IM or SC, every 5 days, then weekly for six treatmentsc


15–20 mg/kg, PO or IM, bid


25 mg/kg, PO, bid for 14 days for Giardia, Clostridium


2.5 mg/kg/day, PO


50–100 mg/kg, PO, bid

a Most are unapproved for use in birds, and caution is indicated.

b May vary with etiology and species treated

c Duration and dosage for treatment of Chlamydia


(Psittacosis, Ornithosis)

Chlamydia psittaci is an obligate intracellular bacterium that can infect all companion birds but is especially common in cockatiels, budgerigars, and parrots. Current state and federal regulations governing the testing, reporting, treatment, and quarantine for Chlamydia should be followed.

The incubation period of C psittaci is from 3 days to several weeks. The organism is excreted in the feces and in nasal and ocular discharge of infected birds. Although labile in the environment, the organism can remain infectious in organic debris for >1 mo.

Clinical signs range from asymptomatic carriers to severe disease and may include ocular, nasal, or conjunctival irritation and discharge; anorexia; dyspnea; depression; dehydration; polyuria; biliverdinuria; and diarrhea. Clinically ill birds may have a leukocytosis, monocytosis, and increased AST and bile acid concentrations. Radiographs may reveal hepatomegaly, splenomegaly, or airsacculitis.

Diagnosis of C psittaci can be challenging, especially in the absence of clinical signs. Few laboratories will culture the organism. Various antibody and antigen tests are available, but these have limitations. Serologic tests available include indirect fluorescent antibody, complement fixation, ELISA, and fluorescent antibody. A positive serologic test result is evidence that a bird has been infected but might not indicate active infection. Exposed but clinically normal birds may produce appreciable antibody titers. Acutely ill birds may not mount an antibody response, also yielding false-negative results. These factors make an antibody test an insufficient screening tool for chlamydiosis in birds when used alone. Because of the intracellular nature of Chlamydia and the reduction in numbers of organisms that accompanies antibiotic use, false-negative results of antigen tests are common. With the advent of PCR testing, diagnosis of Chlamydia is more readily accomplished, and attempts to culture the organism or identify elementary bodies in tissue specimens are rarely done. Laboratories should be consulted before shipment to identify appropriate samples and shipping methods. Because of the difficulty in diagnosing Chlamydia, a single test method may not be adequate, and a PCR assay of a combined conjunctival, choanal, and cloacal swab sample, in conjunction with a serologic test, is recommended.

Doxycycline is commonly used for treatment of Chlamydia infection. Because the treatment period required to eliminate the organism is uncertain, treatment for 45 days is recommended. Dietary calcium sources should be reduced if doxycycline is administered orally. Clinically ill birds should be treated with oral or injectable doxycycline initially to establish therapeutic drug levels quickly. Formulations of doxycycline in the food or water and chlortetracycline-impregnated seeds or other foods are available or can be manufactured to treat infected flocks. A doxycycline-medicated feed for budgerigars can be created by combining 300 mg of doxycycline hyclate (from capsules) with 1 kg of a mixture of oats, millet, and sunflower oil (1 part cracked steel oats is mixed with 3 parts hulled millet; add 5–6 mL of sunflower oil per kg of the oat/seed mixture). Fresh medicated mix should be made daily and fed as the sole diet for 30 days. Doxycycline may also be added to the water for cockatiels (200–400 mg doxycycline hyclate/L of water), Goffin’s cockatoos (400–600 mg/L), and African grey parrots (800 mg/L). A doxycycline syrup, using a monohydrate- or calcium-syrup formulation, can be given at 40–50 mg/kg/day, PO, to cockatiels, Senegal parrots, and blue-fronted and orange-winged Amazon parrots; in African grey parrots, Goffin’s cockatoos, blue and gold macaws, and green-winged macaws, the recommended dosage is 25 mg/kg/day, PO. These indirect modes of antibiotic administration depend on ingesting sufficient quantities of antibiotics to maintain effective blood levels, which may not always occur. Only certain formulations of doxycycline can be given IM or SC. Doxycycline injectable has been successful at 75–100 mg/kg every 5–7 days for 6 wk.

Because C psittaci is transmissible to people, the zoonotic risk must be considered when designing the diagnostic and therapeutic plan. Current state and federal regulations governing the testing, reporting, treatment, and quarantine for birds infected with Chlamydia should be followed. A compendium of control measures is available at

Avian Mycobacteriosis

Avian mycobacteriosis infections are usually caused by Mycobacterium avium and M genavense. Mycobacterium intracellulare, M bovis, and M tuberculosis are less commonly reported. Psittacine birds most commonly infected are brotogeris parakeets and Amazon parrots. Avian mycobacteriosis is a chronic progressive disease affecting the liver and GI tract. Clinical signs include anorexia, weight loss, depression, and diarrhea. Birds with early infections may show few clinical signs.

Diagnosis of mycobacterial infection can be challenging and is most reliably done by acid-fast staining, culture, and/or DNA probe of a biopsy specimen. Biopsy of the liver, intestines, spleen, or a suspected mass is recommended; however, PCR testing of ultrasound-guided fine-needle aspirates of the liver may be diagnostic. Avian mycobacteria are difficult to culture, so a negative culture result does not exclude infection. A fecal acid-fast stain has poor sensitivity but may identify birds shedding large numbers of organisms; PCR testing of a fecal sample is a more sensitive test method. Most birds will have a significant leukocytosis with a monocytosis. Radiographs may reveal hepatomegaly and splenomegaly. Granulomas may occur that may be confused with tumors.

If infected birds are in a multiple bird collection, determining whether other birds are infected can be difficult. Husbandry and sanitation should be assessed. High-risk birds should be isolated and monitored by serial examinations (weights), CBCs, and fecal acid-fast stains or PCR testing.

Treatment involves combination antibiotic therapy for 6–12 mo or longer. Owner compliance is critical and should be discussed at length before beginning treatment. Use of multiple antibiotics (typically three) is recommended, because mycobacterial organisms are prone to developing antibiotic resistance. Antibiotics in differing combinations that have been used successfully are rifabutin (45 mg/kg), clarithromycin (60–85 mg/kg), ethambutol (30 mg/kg), and enrofloxacin (20–30 mg/kg). All combinations are used daily.

Birds with advanced disease and granuloma formation have a poor prognosis. Although human infection has not been associated with exposure to birds, precautions should be taken for zoonotic risk, especially in immunocompromised people.

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