Relationship of Codon Changes in the PNRP Gene to Scrapie Susceptibility or Resistance in Sheep and Goats.
Genotype | Susceptible | Partially Resistant | Resistant |
|---|---|---|---|
Sheep (codons 136, 154, 171) | VRQ/VRQ ARQ/VRQ ARQ/ARQ Commonly known as QQ | ARR / heterozygous AHQ / heterozygous | ARR/ARR, commonly known as RR |
Goats (codons 146, 222) | NQ/NQ | SQ/SQ NQ/SQ NQ/SK NQ/NK NK/NK | Unknown |
Abbreviations are the standard one-letter abbreviations for amino acids: A, Alanine; H, Histidine; K, Lysine; N, Asparagine; Q, Glutamine; R, Arginine; S, Serine; V, Valine. Codons are listed in numerical order. For example, V136R154Q171 is written as VRQ. | |||