Drugs Commonly Used to Treat Sugar Glidersa

Drug

Dosageb

Considerations

Antimicrobials

Amoxicillin (1, 2, 3)

30 mg/kg, PO or SC, q 12–24 h

For dermatitis

Amoxicillin–clavulanic acid (1, 2 3)

12.5 mg/kg, PO, q 12 h

Broad-spectrum against anaerobes and aerobes

Chloramphenicol (1, 2)

50 mg/kg, PO, q 12 h

Can rarely cause bone marrow suppression in humans

Clindamycin (1, 4)

5.5–10 mg/kg, PO, q 12 h

For periodontal disease

Enrofloxacin (1, 3, 4, 5)

2.5–5 mg/kg, PO, SC, or IM, q 12–24 h (1, 3, 4, 5)

10 mg/kg, PO, q 24 h (4)

Potential tissue necrosis when injected

Marbofloxacin (1, 6)

2–5 mg/kg, PO, SC, or IM, q 24 h

Metronidazole (1, 3)

25 mg/kg, PO, q 12–24 h for 7–10 days

Possible CNS toxicosis at high doses or if underlying hepatic disease; use benzoate form

Penicillin procaine (2, 3)

22,000–25,000 IU/kg, SC or IM, q 12–24 h

Trimethoprim-sulfonamide (1, 2, 3, 4, 5, 7, 8)

10–20 mg/kg, PO, q 12–24 h

Antiparasitics

Carbaryl 5% powder (2, 3)

Topically or in cage, sparingly

Use small amounts to treat ectoparasites

Fenbendazole (1, 2, 3, 4, 9)

20–50 mg/kg, PO, q 24 h for 3 days

For roundworms, hookworms, whipworms, tapeworms, lower dose preferable

Imidacloprid (9, 10)

10 mg/kg, topically, q 30 days

Fleas

Ivermectin (1, 2, 3, 9)

0.2 mg/kg, PO or SC, once; repeat in 7–14 days for up to 3 treatments

For roundworms, hookworms, whipworms, nematodes, mites

Metronidazole (1, 2, 11, 12, 13)

25 mg/kg, PO, q 12–24 h

For intestinal protozoa; possible CNS toxicosis at high doses or if underlying hepatic disease; use benzoate form

Piperazine (1, 12)

50–100 mg/kg, PO, q 24 h

For nematodes

Praziquantel (5, 14)

5–10 mg/kg, PO or SC, once; repeat in 10–14 days

For cestodes, trematodes

Pyrethrin powder (12)

Topically, as needed

For ectoparasites; use products formulated for kittens

Selamectin (1, 2, 11, 15, 16)

6–18 mg/kg, topically, once; repeat in 30 days

For ectoparasites; not effective against Demodex

Antifungals

Itraconazole (1, 2, 3)

5–10 mg/kg, PO, q 12–24 h

For dermatophytes

Nystatin (3, 4, 9, 11)

2,000–10,000 IU/kg, PO, q 8 h for 3 days

For Candida

Analgesics

Buprenorphine (2, 3, 4, 8, 17)

0.005–0.05 mg/kg, PO, SC, or IM, q 8–12 h

Butorphanol (1, 2, 3, 4)

0.1–0.5 mg/kg, SC or IM, q 6–8 h

Possible sedation at higher doses

Gabapentin (18, 19)

3–5 mg/kg, PO, q 8–24 h

For neurotropic pain and anxiety; possible sedation at higher doses

Tramadol (4, 17, 20)

2–10 mg/kg, PO or IM, q 12 h

Anti-inflammatories

Meloxicam (1, 2, 3, 7, 8, 12, 17)

0.1–0.2 mg/kg, PO or SC, q 24 h

0.5 mg/kg, PO, q 24 h (17)

NSAID

Prednisolone (1, 2, 3, 21)

0.1–0.2 mg/kg, PO, SC, or IM, q 24 h

Corticosteroid

Preanesthetics

Atropine (1, 2, 12)

0.01–0.04 mg/kg, IM, SC, or IV

To lessen intraoperative secretions, prevent and correct bradycardia

Glycopyrrolate (1, 2)

0.01–0.02 mg/kg, IM, SC, or IV

To lessen intraoperative secretions, prevent and correct bradycardia

Anesthetics

Bupivacaine (2, 22)

1–2 mg/kg, local infiltration

Local anesthesia

Buprenorphine (Bu) + midazolam (Mi) + meloxicam (Me) (5)

0.01 mg/kg Bu + 0.1 mg/kg Mi + 0.2 mg/kg Me, IM

Butorphanol (9)

0.4–1 mg/kg, SC or IM

Diazepam (1, 2, 12)

0.5-2 mg/kg, PO, SC, IM, or IV

Sedative, anticonvulsant

Isoflurane (1, 5, 23)

1–5%, via face mask or intubation

Ketamine (2, 3)

20–50 mg/kg, IM

Ketamine + midazolam (2, 3)

10–20 mg/kg + 0.35–0.5 mg/kg, SC or IM

Administer ketamine 10 min after midazolam

Lidocaine (22, 23)

As a 2% injection, ≤ 0.2 mL/kg (< 4 mg/kg), local infiltration

Local anesthesia

Midazolam (1, 2, 3, 5, 24)

0.1–0.5 mg/kg, SC, IM, IV, or intranasal

Sedative, anxiolytic, anticonvulsant; preferred over diazepam for injection

Sevoflurane (3)

1–5%, via face mask or intubation

Possible toxicosis; use cautiously

Anesthetic Reversal Drugs

Flumazenil (18, 25)

0.02–0.1 mg/kg, SC or IM

For reversal of diazepam and midazolam

Cardiac Drugs

Enalapril (1, 2, 26)

0.5 mg/kg, PO, q 24 h

ACE inhibitor

Furosemide (1, 12, 26, 27)

1–5 mg/kg, PO, SC or IM, q 6–12 h

Diuretic

Pimobendan (1)

0.3-0.5 mg/kg, PO, q 12 h

Positive inotrope and vasodilator

GI Drugs

Cisapride (1, 3, 4, 27)

0.1–0.25 mg/kg, PO or SC, q 8–24 h

GI motility enhancer

Maropitant citrate (2)

0.2 mg/kg, SC, q 24 h

Metoclopramide (1, 3, 4, 9, 28)

0.05–0.1 mg/kg, PO, SC, or IM, q 6–12 h

GI motility enhancer

Hormones

Calcitonin (3)

50–100 IU/kg, SC or IM, q 7 d

Aid to calcium mobilization; calcium levels should be normal before use

Vitamins and Minerals

Calcium glubionate (1, 3, 27)

150 mg/kg, PO, q 24 h

Calcium supplement

Calcium gluconate (1, 27, 29)

100 mg/kg, SC, q 12 h for 3–5 days

Calcium supplement; dilute to 10 mg/mL solution in saline

Vitamin A (1, 3)

500–5,000 IU/kg, IM, once (3)

50–500 IU/kg IM (1)

For dermatitis

Vitamin B complex (1, 2, 3)

0.01–0.2 mL/kg, SC or IM

Inject into SC fluids to decrease pain (stings on injection)

Vitamin E (1, 3, 11)

25–100 IU/glider, SC, q 24 h

Vitamin K (1, 2, 3, 4, 9)

2 mg/kg, PO or SC, q 24–72 h (1, 2, 3)

2.5 mg/kg, SC, once; then 5 mg/kg, PO, q 24 h for 14 days (4, 9)

For intestinal and liver disease

Treatment for anticoagulant rodenticide poisoning

Other

Dextrose (20%) (9)

2–5 mL/kg, IV, slow

For hypoglycemia

Doxapram (1, 2)

2 mg/kg, SC, IM, IV, or sublingual

Respiratory stimulant

Abbreviations: ACE, angiotensin-converting enzyme.

aData are from the following sources:

  1. Hedley J. BSAVA Small Animal Formulary. Part B, Exotic Pets. 10th ed. British Small Animal Veterinary Association; 2020.

  2. Morrisey JK, Carpenter JW. Appendix: formulary. In: Quesenberry KE, Orcutt CJ, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 4th ed. Elsevier; 2021:620-630.

  3. Ness RD, Johnson-Delaney C. Sugar gliders. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 3rd ed. Saunders/Elsevier; 2012:393-410.

  4. Bodley K. Appendix 4. Drug formulary. In: Vogelnest L, Portas T, eds. Current Therapy in Medicine of Australian Mammals. CSIRO Publishing; 2019:702-727.

  5. Brust DM, Mans C. Sugar gliders. In: Carpenter JW. Exotic Animal Formulary. 5th ed. Elsevier; 2018:432-442.

  6. Bassan T, Cobos A, Mallol C, Abarca ML, Martorell J. Reproductive tract infection caused by Kocuria kristinae in an entire female sugar glider (Petaurus breviceps). Vet Rec Case Rep. 2022;10(4):e507. doi:10.1002/vrc2.507

  7. Thomas M, Parkinson L, Shaw G, Mans C. Paracloacal cyst in a sugar glider (Petaurus breviceps). J Exot Pet Med. 2019;29:40-44. doi:10.1053/j.jepm.2018.02.046

  8. Fisher CJ, Tovar-Lopez G, Schiavone S, Muñoz Gutiérrez JF, Watson AM, Sadar MJ. Microchip implant induced dermatitis and self-mutilation in four sugar gliders. J Exot Pet Med. 2022;42:20-25. doi:10.1053/j.jepm.2022.04.003

  9. Johnson R, Hemsley S. Gliders and possums. In: Vogelnest L, Woods R, eds. Medicine of Australian Mammals. CSIRO Publishing; 2008:395-437.

  10. Baker RT, Beveridge I. Imidacloprid treatment of marsupials for fleas (Pygiopsylla hoplia). J Zoo Wildl Med. 2001;32(3):391-392. doi:10.1638/1042-7260(2001)032[0391:ITOMFF]2.0.CO;2

  11. Brust DM. Sugar Gliders: A Complete Veterinary Care Guide. Veterinary Interactive Publications; 2009.

  12. Hess L. Sugar gliders. In: Aiello SE, Moses MA, eds. Merck Veterinary Manual. Merck & Co.; 2016:2035-2043.

  13. Brust DM. Gastrointestinal diseases of marsupials. J Exot Pet Med. 2013;22(2):132-140. doi:10.1053/j.jepm.2013.05.005

  14. Pye GW. Personal communication; 2016.

  15. Pye GW, Carpenter JW. A guide to medicine and surgery in sugar gliders. Vet Med. 1999;94:891-905.

  16. Vogelnest L. Dermatology. In: Vogelnest L, Portas T, eds. Current Therapy in Medicine of Australian Mammals. CSIRO Publishing; 2019:181-206.

  17. Keller KA, Nevarez JG, Rodriguez D, Gieger T, Gumber S. Diagnosis and treatment of anaplastic mammary carcinoma in a sugar glider (Petaurus breviceps). J Exot Pet Med. 2014;23(3):277-282. doi:10.1053/j.jepm.2014.06.008

  18. Johnson-Delaney CA. Personal communication; 2020.

  19. McCready JE, Fisher J, McCleery B. Clinical, imaging and pathological features of hepatic carcinosarcoma in a sugar glider (Petaurus breviceps). Vet Rec Case Rep. 2024;12(1):e764.

  20. Chen J-C, Yu P-H, Liu C-H, Chi C-H. Paracloacal gland carcinoma in a sugar glider (Petaurus breviceps). J Exot Pet Med. 2018;27(1):36-40. doi:10.1053/j.jepm.2017.10.019

  21. Lindemann DM, Carpenter JW, DeBey BM, Ryseff JK. Concurrent adrenocortical carcinoma and hepatocellular carcinoma with hemosiderosis in a sugar glider (Petaurus breviceps). J Exot Pet Med. 2016;25(2):144-149. doi:10.1053/j.jepm.2016.03.013

  22. Miwa Y, Sladky KK. Small mammals: common surgical procedures of rodents, ferrets, hedgehogs, and sugar gliders. Vet Clin North Am Exot Anim Pract. 2016;19(1):205-244. doi:10.1016/j.cvex.2015.09.001

  23. Johnson-Delaney CA. Sugar gliders. In: Quesenberry KE, Orcutt CJ, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 4th ed. Elsevier; 2021:385-400.

  24. Rivas AE, Pye GW, Papendick R. Dermal hemangiosarcoma in a sugar glider (Petaurus breviceps). J Exot Pet Med. 2014;23(4):384-388. doi:10.1053/j.jepm.2014.07.001

  25. Koizumi I, Okumura N, Kondo H. Pyometra in a sugar glider (Petaurus breviceps): surgical treatment and postoperative complications. J Vet Med Sci. 2023;85(11):1252-1256. doi:10.1292/jvms.23-0117

  26. Lennox AM. Emergency and critical care procedures in sugar gliders (Petaurus breviceps), African hedgehogs (Atelerix albiventris), and prairie dogs (Cynomys spp). Vet Clin North Am Exot Anim Pract. 2007;10(2):533-555. doi:10.1016/j.cvex.2007.01.001

  27. Brust DM. What every veterinarian needs to know about sugar gliders. Exotic DVM. 2009;11(3):32-41.

  28. Nojiri K, Kondo H, Nagamune M, Yamashita T, Shibuya H. First case of hemochromatosis in a sugar glider (Petaurus breviceps). J Vet Med Sci. 2023;85(2):194-198. doi:10.1292/jvms.22-0361

  29. Kubiak M. Sugar gliders. In Handbook of Exotic Pet Medicine. Kubiak M, ed. John Wiley & Sons; 2021:125-139.

bDuration of treatment, when not specified by a referenced study, is at the discretion of the prescriber and depends on the condition being treated.