Generalized Skeletal Dysplasias Affecting Large Animals
Dysplasia | Nature of the Disorder | Large Animal Species Affected |
|---|---|---|
Chondrodysplasia | A genetic defect compromises the ability to undergo endochondral ossification; thus the ability to form cartilage and bone from cartilage is lost. | Horses, cattle, sheep, pigs |
Osteogenesis imperfecta | A defect in type 1 collagen formation in bone results in osteopenia and excessive bone fragility, with multiple intrauterine fractures, skeletal deformity, fetal death, fragile teeth, joint laxity, and blue sclera. | Cattle, sheep |
Osteopetrosis | A primarily genetic inherited disorder causes a defect in osteoclastic bone resorption, resulting in accumulation of primary spongiosa within the medullary cavities and overall systemic increase in skeletal mass. | Cattle, horses, deer |
Disproportionate dwarfism | An inherited, genetic disorder results from disrupted signaling pathways or structural disruptions. Physical characteristics are breed-specific. | Cattle, horses, sheep, goats |