Merck Manual

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Great Dane Myopathy


Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Jan 2021

Inherited myopathy of Great Danes is a noninflammatory condition of young Great Danes. Affected dogs have been identified in England, Australia, and Canada. An autosomal recessive mode of inheritance is suspected. Clinical signs include exercise-induced tremors, weakness, and muscle wasting. CK activity is usually increased, fibrillation potentials are detected in skeletal muscles, and histopathology reveals a central core myopathy. Treatment is supportive, at best.

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