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Find information on animal health topics, written for the veterinary professional.

Great Dane Myopathy

By Joseph Harari, MS, DVM, DACVS, Veterinary Surgeon, Veterinary Surgical Specialists, Spokane, WA

Inherited myopathy of Great Danes is a noninflammatory condition of young Great Danes. Affected dogs have been identified in England, Australia, and Canada. An autosomal recessive mode of inheritance is suspected. Clinical signs include exercise-induced tremors, weakness, and muscle wasting. CK activity is usually increased, fibrillation potentials are detected in skeletal muscles, and histopathology reveals a central core myopathy. Treatment is supportive, at best.