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Great Dane Myopathy

By

Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Nov 2020

Inherited myopathy of Great Danes is a noninflammatory condition of young Great Danes. Affected dogs have been identified in England, Australia, and Canada. An autosomal recessive mode of inheritance is suspected. Clinical signs include exercise-induced tremors, weakness, and muscle wasting. CK activity is usually increased, fibrillation potentials are detected in skeletal muscles, and histopathology reveals a central core myopathy. Treatment is supportive, at best.

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In all animals, the motor unit of skeletal muscle consists of the motor neuron, the neuromuscular junction, and muscle fibers. Muscle dysfunction—such as ataxia, paresis, or paralysis—most commonly originates in which of the following locations?
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