Merck Manual

Please confirm that you are a health care professional

honeypot link

Malignant Hyperthermia in Dogs

By

Joseph Harari

, MS, DVM, DACVS, Veterinary Surgical Specialists, Spokane, WA

Last full review/revision Nov 2020 | Content last modified Nov 2020

Malignant hyperthermia Malignant Hyperthermia read more is a hypermetabolic disorder of skeletal muscle characterized by catabolism and contracture, usually secondary to inhalant anesthetic agents and stress. It is seen most frequently in heavily muscled dogs. Abnormal calcium regulation, glycogenolysis, and contractile protein activity result in production of heat, CO2, and lactic acid.

Clinical signs include tachycardia, tachypnea, fever, muscle rigidity, and cardiopulmonary failure. Signs develop 5–30 minutes after exposure to the anesthetic agent. Treatment consists of immediate cessation of anesthesia and hyperventilation with oxygen. IV fluid therapy, corticosteroids, and ice packs are also used. Dantrolene, a muscle relaxant, may be given at 2–5 mg/kg, IV. Prognosis is poor in severe cases. Urinary output, serum potassium levels, and cardiac function should be monitored.

For More Information

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Test your knowledge
Musculoskeletal Disorders in Large Animals
A seven-year-old Quarter horse gelding presents with a 1-week history of mild lameness. During the examination, the horse raises his head as he places weight on his left forelimb and drops it when placing weight on the right forelimb. Which limb is most likely affected in this horse?
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website 
TOP