Merck Manual

Please confirm that you are a health care professional

honeypot link
Professional Version

Amino-acetonitrile Derivatives

By

Jozef Vercruysse

, DVM, Ghent University;


Edwin Claerebout

, DVM, PhD, DEVPC, Laboratory of Parasitology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Belgium

Reviewed/Revised Sep 2014 | Modified Nov 2022

Amino-acetonitrile derivatives are a class of synthetic compounds with high activity against GI nematodes, including isolates resistant to all other commercially available broad-spectrum anthelmintic classes, because of their novel mode of action. Efficacy studies have shown that monepantel (2.5 mg/kg, PO) effectively controls adult and L4 stages of ruminant nematodes, including strains that are resistant or multidrug resistant to the other currently available broad-spectrum anthelmintic classes.

quiz link

Test your knowledge

Take a Quiz!
iOS ANDROID
iOS ANDROID
iOS ANDROID
TOP