Causes of slaframine toxicosis include the ingestion of forages, particularly clovers, infected with the fungus Rhizoctonia leguminicola, which produces the toxic alkaloid slaframine. Profuse ptyalism is often the only clinical sign. Affected animals have no evidence of oral ulceration or other oral lesions. Ptyalism resolves once the animal is removed from the affected forage. The differential diagnoses for large animals (particularly ruminants) include bluetongue Bluetongue in Ruminants Bluetongue is a viral disease of ruminants worldwide. Clinical signs in sheep result from vascular endothelial damage, including edema of the muzzle, tongue, and coronary bands. Diagnosis is... read more , vesicular stomatitis Vesicular Stomatitis in Large Animals Vesicular stomatitis is a viral disease of primarily horses and cattle, transmitted mainly by biting flies and midges. The disease results in characteristic vesicular lesions that can occur... read more , vesicular exanthema Vesicular Exanthema of Swine Vesicular exanthema of swine (VES) is an acute, highly infectious disease characterized by fever and formation of vesicles on the snout, oral mucosa, soles of the feet, coronary bands, and between... read more , and foot-and-mouth disease Foot-and-Mouth Disease in Animals Foot-and-mouth disease is one of the world's most economically important viral diseases of livestock. The virus infects cattle, pigs, and sheep and many cloven-hoofed wildlife species. The infection... read more .