Tissue plasminogen activator (t-PA) is an antifibrinolytic that converts plasminogen to the serine proteinase plasmin. It is used intracamerally after cataract surgery to break down anterior chamber fibrin.
Collagen cross-linking using topical riboflavin and UV-A light is used in the treatment of infectious and melting cornea ulcers and bullous keratopathy. The combination causes the formation of new covalent bonds between collagen fibrils increasing corneal stability. There are species differences in the penetration of topical riboflavin into the corneal stroma, and care is needed to avoid possible UV-A–induced endothelial damage in thin corneas.
An aldose reductase inhibitor for use in diabetic dogs to prevent the development of sorbitol cataracts is currently awaiting FDA review.
In theory, antioxidants have the potential to decrease progression of cataracts; however, none have been clinically proved to do so. Their use can delay opportune intervention to prevent permanent loss of vision (ie, lens-induced uveitis, progression to hypermature and secondary retinal detachment).
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Also see pet health content regarding drugs used to treat eye disorders Drugs Used to Treat Eye Disorders The 3 primary methods of administering medications to the eye are topical, local ocular (such as under the conjunctival tissue or into the vitreous portion of the eye), and systemic (given by... read more .