Merck Manual

Please confirm that you are a health care professional

honeypot link

Coagulation Disorders in Animals


Susan M. Cotter

, DVM, DACVIM (Small Animal Internal Medicine and Oncology), Tufts University

Last full review/revision May 2019 | Content last modified Oct 2020

Bleeding diatheses may be caused by congenital or acquired defects in the vasculature, platelets, or the coagulation proteins. Congenital or acquired defects or deficiencies of platelets usually manifest as superficial petechial and ecchymotic hemorrhages (especially of mucous membranes), epistaxis, melena, or prolonged bleeding at injection and incision sites, whereas congenital or acquired deficiencies in coagulation proteins usually manifest clinically as delayed or recurring deep tissue hemorrhage, hematoma formation, and bleeding into joints and body cavities. Petechiae are generally not seen in conditions caused by abnormalities in coagulation proteins.

Pathologic thrombosis may occur because of primary or inherited disorders of anticoagulant protein factors or more commonly because of secondary or acquired disorders. Collectively, these conditions are called hypercoagulable states. Syndromes, such as DIC, that enhance platelet responsiveness to agonists and alter the balance between anticoagulant and procoagulant protein factors or that increase the reactivity of endothelium are always secondary to some other disease or injury which must be recognized and treated for a successful outcome. DIC is more common in animals than are inherited disorders.

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Test your knowledge
Circulatory System
A 10-year-old, male-castrated golden retriever has a 1-month history of mild lethargy and decreased appetite. On physical examination, he has pale mucous membranes and weak femoral pulses. His complete blood count (CBC) shows a decreased packed cell volume (PCV), decreased mean corpuscular volume (MCV), and decreased mean corpuscular hemoglobin concentration (MCHC). His biochemistry panel shows a mildly increased blood urea nitrogen (BUN) level and mildly increased serum alkaline phosphatase (ALP) level. Which of the following is the most likely cause of this dog’s anemia? 
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website